Autoantibody Screen (includes: ANA, Smooth Muscle, Mitochondrial and Liver Kidney Antibodies)

Pathology category

Immunology

Code

AAS

Referral code

RHH

Request form

Test information

Liver kidney microsomal ab’s (LKM) are positive in autoimmune chronic active hepatitis.Mitochondrial ab’s M2 type is present in >95% of cases of primary biliary cirrhosis. Other types are associated with a wide range of conditions.Smooth muscle ab’s These are present in high titres in 50-70% of patients with type 1 autoimmune hepatitis. They may also be seen in other types of autoimmune hepatitis, primary biliary cirrhosis and chronic viral hepatitis.

Guidelines

Pre-analytical

Reference range

Tube type

Tube type info

SST, Plain or Lithium Heparin

Special requirements

Plasma or Serum

Minimum volume

Assay frequency

Twice weekly

TAT Inpatient (urgent)

TAT Inpatient

TAT GP/Outpatient

up to 7 days

Referral lab

Immunology Russells Hall Hospital